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Scaffolds for Islets Vascularization

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Mimicking Tissue Organization at Multiple Scaleswith Biofabrication

Many tissues in our body display a variable degree of fiber curliness, which is crucial for their biomechanical behaviour. Methods to replicate such features in scaffolds for regenerative medicine are limited. Here, we show how by simply applying controlled buckling to electrospun fibers, we can fabricate scaffolds with different degrees of fiber waviness at multiple scales.

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Towards Kidney bioprinting

Certainly bioprinting of a full kidney remains a dream. It will be probably like that for many decades, unless a strong and well funded collaborative effort will be originated in the near future. However, current kidney bioprinting attempts are helping creating more know-how over kidney biology through the biofabrication of 3D in vitro models that can be used to study new treatments for kidney chronic conditions.

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World TERMIS 2021

After Seoul, Vienna, and Boston, Maastricht was selected to host the next world conference of the tissue engineering and regenerative medicine society. We expect to attract more than 2'000 delegates by 2021 in Maastricht, which is at the center of a European region fervidly active in tissue engineering, regenerative medicine, stem cells, biomaterials, in silico modeling, and biofabrication.

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Biofabrication for the eardrum

Tympanic membrane (or eardrum) is provided by nature with unique anatomic features that ultimately allow a superb physiologic performance in varying frequency ranges. Several pathologies damage this tissue, including chronic otitis media (COM), which ultimately bring to deafness.

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Biofabrication with dynamic materials

3D printing makes it possible to create complex personalized products such as prostheses and implants directly from a 3D scan. To make this type of application possible, it is important that available materials have the correct mechanical and biochemical properties. In the TA program DYNAM, which is funded from the Innovation Fund for Chemistry, researchers and companies will tackle this challenge

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Scaffolds for Islets Vascularization
Published on: May 10, 2016
Category: Group Activities

Biofabrication strategies aiming at creating new solutions for the transplantation of islets of Langerhans for diabetic patients are becoming more and more appealing, thanks to their potential to more closely approach the complexity of the native environment. After having shown for the first time that bioprinting can be used to deliver islets of Lagerhans without affecting their viability, we further investigate the use of 3D printed functionalized scaffolds to recruit the host vasculature in a CAM model. Our results show that for an optimum concentration of bound vascular endothelial growth factor, vessels could be recruied without affecting their morphology. Furthermore, islets of Langerhans embedded in the core of the 3D printed constructs maintained their functionality to respond at different glucose regimes.

Although the road to clinical applications is still long and tortuous, these studies lay the first steps to possibly more efficient treatments for diabetic patients.