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Scaffolds for Islets Vascularization
Category: Group Activities
Biofabrication strategies aiming at creating new solutions for the transplantation of islets of Langerhans for diabetic patients are becoming more and more appealing, thanks to their potential to more closely approach the complexity of the native environment. After having shown for the first time that bioprinting can be used to deliver islets of Lagerhans without affecting their viability, we further investigate the use of 3D printed functionalized scaffolds to recruit the host vasculature in a CAM model. Our results show that for an optimum concentration of bound vascular endothelial growth factor, vessels could be recruied without affecting their morphology. Furthermore, islets of Langerhans embedded in the core of the 3D printed constructs maintained their functionality to respond at different glucose regimes.
Although the road to clinical applications is still long and tortuous, these studies lay the first steps to possibly more efficient treatments for diabetic patients.