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Mimicking Tissue Organization at Multiple Scaleswith Biofabrication

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Mimicking Tissue Organization at Multiple Scaleswith Biofabrication

Many tissues in our body display a variable degree of fiber curliness, which is crucial for their biomechanical behaviour. Methods to replicate such features in scaffolds for regenerative medicine are limited. Here, we show how by simply applying controlled buckling to electrospun fibers, we can fabricate scaffolds with different degrees of fiber waviness at multiple scales.

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Towards Kidney bioprinting

Certainly bioprinting of a full kidney remains a dream. It will be probably like that for many decades, unless a strong and well funded collaborative effort will be originated in the near future. However, current kidney bioprinting attempts are helping creating more know-how over kidney biology through the biofabrication of 3D in vitro models that can be used to study new treatments for kidney chronic conditions.

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World TERMIS 2021

After Seoul, Vienna, and Boston, Maastricht was selected to host the next world conference of the tissue engineering and regenerative medicine society. We expect to attract more than 2'000 delegates by 2021 in Maastricht, which is at the center of a European region fervidly active in tissue engineering, regenerative medicine, stem cells, biomaterials, in silico modeling, and biofabrication.

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Biofabrication for the eardrum

Tympanic membrane (or eardrum) is provided by nature with unique anatomic features that ultimately allow a superb physiologic performance in varying frequency ranges. Several pathologies damage this tissue, including chronic otitis media (COM), which ultimately bring to deafness.

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Biofabrication with dynamic materials

3D printing makes it possible to create complex personalized products such as prostheses and implants directly from a 3D scan. To make this type of application possible, it is important that available materials have the correct mechanical and biochemical properties. In the TA program DYNAM, which is funded from the Innovation Fund for Chemistry, researchers and companies will tackle this challenge

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Mimicking Tissue Organization at Multiple Scaleswith Biofabrication
Published on: July 15, 2019
Category: Events

In a recent paper published in RSC Nanoscale, we show a new method to curl fibers and fibrous scaffolds at different scales. The method is simple and straightforward, allowing to generate different level of fiber waves depending on the shrinking of aligned crystlline substrates. The resulting scaffolds show two unique behaviours: on one side they allow a much better cellular infiltration over thick meshes, on the other side they promote the secretion of TGF-ß1 known to be a potent morphogenetic factor in several tissue regeneration processes.

For more information:

https://pubs.rsc.org/en/content/articlelanding/2019/nr/c8nr10108f#!divAbstract