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Mimicking Tissue Organization at Multiple Scales with Biofabrication
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New Hybrid Biofabrication technology
Many tissues in our body display gradients. These are not only biological gradients, but also structural, physical, and chemical ones, resulting in smoother variations of mechanical properties and cell functional activity.
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Kidney 3D in vitro models through bioprinting
At the Complex Tissue Regeneration department, we work hard to bridge the gap towards the dream of organs bioprinting. Step by step, we are now progressing towards understanding more and more in depth the requirements to bioprint different kidney cells, either derived from pluripotent stem cells or of adult species.
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Bioprinting through Levitation
Magnetic levitation offers the possibility to place cells in a precise position in space through controlling the magnetic forces applied to magnetized cells. This new biofabrication technique, at the interface between bioprinting and bioassembly, provides new ways to create large-scale biological constructs that can be used for regenerative medicine purposes.
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SINERGIA: biofabrication for 3D in vitro models
We are excited to have been selected for funding in a Marie Curie project called SINERGIA, which aims at developing advanced models of human physiology and diseases, to be ultimately introduced in the preclinical stages of the drug discovery pipeline.
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Moroni Lab Broadcasted on Biofabrication
Biofabrication has witnessed several advances in this past months, spanning from new technologies, to promising steps forward in several tissue regeneration applications.
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Published on: July 15, 2019
Category: Events
In a recent paper published in RSC Nanoscale, we show a new method to curl fibers and fibrous scaffolds at different scales. The method is simple and straightforward, allowing to generate different level of fiber waves depending on the shrinking of aligned crystlline substrates. The resulting scaffolds show two unique behaviours: on one side they allow a much better cellular infiltration over thick meshes, on the other side they promote the secretion of TGF-ß1 known to be a potent morphogenetic factor in several tissue regeneration processes.
For more information:
https://pubs.rsc.org/en/content/articlelanding/2019/nr/c8nr10108f#!divAbstract
