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Mimicking Tissue Organization at Multiple Scales with Biofabrication
In a recent paper published in RSC Nanoscale, we show a new method to curl fibers and fibrous scaffolds at different scales. The method is simple and straightforward, allowing to generate different level of fiber waves depending on the shrinking of aligned crystlline substrates. The resulting scaffolds show two unique behaviours: on one side they allow a much better cellular infiltration over thick meshes, on the other side they promote the secretion of TGF-ß1 known to be a potent morphogenetic factor in several tissue regeneration processes.
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