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Integrating Biofabrication Technologies
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Integrating Biofabrication Technologies
Unlocking the secrets of osteochondral regeneration has long been a daunting challenge, with the intricate interplay between cartilage and bone presenting formidable hurdles. However, a groundbreaking approach is on the horizon, poised to redefine the landscape of tissue regeneration: multiphasic scaffolds – the cornerstone of cutting-edge strategies aimed at mirroring the complexities of the osteochondral unit and nurturing the growth of implanted bone-marrow derived stem cells (BMSCs). Yet, amidst the promise, hurdles remain. Stem cell loss during expansion in vitro and the limited control over their behavior within scaffolds both in vitro and in vivo pose formidable challenges.
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Bioprinting in Space
In a new Pathfinder Open project, PULSE, we have partnered with different experts in space technology and use thereof to study how the Space environment could be working as an accelerator of ageing…
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New Hybrid Biofabrication technology
Many tissues in our body display gradients. These are not only biological gradients, but also structural, physical, and chemical ones, resulting in smoother variations of mechanical properties and cell functional activity.
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Kidney 3D in vitro models through bioprinting
At the Complex Tissue Regeneration department, we work hard to bridge the gap towards the dream of organs bioprinting. Step by step, we are now progressing towards understanding more and more in depth the requirements to bioprint different kidney cells, either derived from pluripotent stem cells or of adult species.
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Bioprinting through Levitation
Magnetic levitation offers the possibility to place cells in a precise position in space through controlling the magnetic forces applied to magnetized cells. This new biofabrication technique, at the interface between bioprinting and bioassembly, provides new ways to create large-scale biological constructs that can be used for regenerative medicine purposes.
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Published on: March 3, 2024
Category: Group Activities
In a remarkable leap forward, researchers have drawn inspiration from the bone marrow niche to unveil a novel paradigm in tissue regeneration. Picture this: scaffolds meticulously crafted to mimic the innate healing processes following injury. These ingenious constructs boast an internal reservoir of quiescent BMSCs, meticulously mirroring the bone marrow cavity. Complementing this, an electrospun (ESP) capsule acts as a catalyst, beckoning cells to venture into an outer "differentiation-inducing" 3D printed unit, meticulously armed with TGF-β and BMP-2 peptides.
In laboratory settings, these niche-inspired scaffolds have proven their mettle. Retaining a pool of nonproliferative cells capable of migration and proliferation, they usher in location-specific cell differentiation, mineralization, and the secretion of vital proteins such as alkaline phosphatase (ALP) and glycosaminoglycans (GAGs). Genetic upregulation of collagen II and collagen I further underscores their prowess.
But the true litmus test lies in the real world – and here, these scaffolds shine. Demonstrating exemplary biocompatibility, they pave the way for tissue formation in rat subcutaneous models and orchestrate the regeneration of the osteochondral unit in rabbit models. With each stride, they herald a new dawn in osteochondral regeneration.
Read the full article: https://onlinelibrary.wiley.com/doi/full/10.1002/adma.202310258
