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New Hybrid Biofabrication technology

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New Hybrid Biofabrication technology

Many tissues in our body display gradients. These are not only biological gradients, but also structural, physical, and chemical ones, resulting in smoother variations of mechanical properties and cell functional activity.

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Kidney 3D in vitro models through bioprinting

At the Complex Tissue Regeneration department, we work hard to bridge the gap towards the dream of organs bioprinting. Step by step, we are now progressing towards understanding more and more in depth the requirements to bioprint different kidney cells, either derived from pluripotent stem cells or of adult species.

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Bioprinting through Levitation

Magnetic levitation offers the possibility to place cells in a precise position in space through controlling the magnetic forces applied to magnetized cells. This new biofabrication technique, at the interface between bioprinting and bioassembly, provides new ways to create large-scale biological constructs that can be used for regenerative medicine purposes.

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SINERGIA: biofabrication for 3D in vitro models

We are excited to have been selected for funding in a Marie Curie project called SINERGIA, which aims at developing advanced models of human physiology and diseases, to be ultimately introduced in the preclinical stages of the drug discovery pipeline.

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Moroni Lab Broadcasted on Biofabrication

Biofabrication has witnessed several advances in this past months, spanning from new technologies, to promising steps forward in several tissue regeneration applications.

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New Hybrid Biofabrication technology
Published on: February 18, 2021
Category: Events

With the final aim to create scaffolds that could better reproduce the physicochemical and structural gradients present in our tissues, we have developed a new hybrid additive manufacturing technology that allows to blend two different materials during fabrication. In addition, an atmospheric plasma pen can further modify the deposited fibers in a layer-by-layer manner by either providing tailored surface topographies or coating.

The work has been recently published in Nature Communication and available at this link: 

https://www.nature.com/articles/s41467-020-20865-y

The work was also possible thanks to the precious collaboration of partners from the H2020 FAST project http://project-fast.eu/en/home and in particular to the contribution of Nadir https://www.nadir-tech.it/en/home-en/ and Prof. Patelli at University of Padova.