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Flexible Ceramics nanofibers for bone scaffolds

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Mimicking Tissue Organization at Multiple Scaleswith Biofabrication

Many tissues in our body display a variable degree of fiber curliness, which is crucial for their biomechanical behaviour. Methods to replicate such features in scaffolds for regenerative medicine are limited. Here, we show how by simply applying controlled buckling to electrospun fibers, we can fabricate scaffolds with different degrees of fiber waviness at multiple scales.

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Towards Kidney bioprinting

Certainly bioprinting of a full kidney remains a dream. It will be probably like that for many decades, unless a strong and well funded collaborative effort will be originated in the near future. However, current kidney bioprinting attempts are helping creating more know-how over kidney biology through the biofabrication of 3D in vitro models that can be used to study new treatments for kidney chronic conditions.

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World TERMIS 2021

After Seoul, Vienna, and Boston, Maastricht was selected to host the next world conference of the tissue engineering and regenerative medicine society. We expect to attract more than 2'000 delegates by 2021 in Maastricht, which is at the center of a European region fervidly active in tissue engineering, regenerative medicine, stem cells, biomaterials, in silico modeling, and biofabrication.

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Biofabrication for the eardrum

Tympanic membrane (or eardrum) is provided by nature with unique anatomic features that ultimately allow a superb physiologic performance in varying frequency ranges. Several pathologies damage this tissue, including chronic otitis media (COM), which ultimately bring to deafness.

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Biofabrication with dynamic materials

3D printing makes it possible to create complex personalized products such as prostheses and implants directly from a 3D scan. To make this type of application possible, it is important that available materials have the correct mechanical and biochemical properties. In the TA program DYNAM, which is funded from the Innovation Fund for Chemistry, researchers and companies will tackle this challenge

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Flexible Ceramics nanofibers for bone scaffolds
Published on: June 20, 2016
Category: Group Activities

Ceramcs are widespread biomaterials in the regenerative medicine field to support bone regeneration. One of the conventional limitation of ceramics is the poor mechanical properties that they typically display. In a nw exciting study that we performed in collaboration with University of Twente, we show our latest development in relation to scaffolds for regenerative medicine applications. By exploiting the versatility of electrospinning, we have created electrospun ceramic nanofibers displaying ifferent mechanical propertiesfrom the macro to the nanoscales. The resulting scaffolds can be designed with tailorable surface properties as well, which result in a differential degree of osteogenic differentiation of adult stem cells.

This development could open new avenues in the feld of bone regeneration where flexible membranes in combination with bioactive properties are desired.

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