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Biofabrication for the eardrum

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World TERMIS 2021

After Seoul, Vienna, and Boston, Maastricht was selected to host the next world conference of the tissue engineering and regenerative medicine society. We expect to attract more than 2'000 delegates by 2021 in Maastricht, which is at the center of a European region fervidly active in tissue engineering, regenerative medicine, stem cells, biomaterials, in silico modeling, and biofabrication.

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Biofabrication for the eardrum

Tympanic membrane (or eardrum) is provided by nature with unique anatomic features that ultimately allow a superb physiologic performance in varying frequency ranges. Several pathologies damage this tissue, including chronic otitis media (COM), which ultimately bring to deafness.

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Biofabrication with dynamic materials

3D printing makes it possible to create complex personalized products such as prostheses and implants directly from a 3D scan. To make this type of application possible, it is important that available materials have the correct mechanical and biochemical properties. In the TA program DYNAM, which is funded from the Innovation Fund for Chemistry, researchers and companies will tackle this challenge

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New Project on 3D printing

Damaged and diseased bones in the region of head, face and jaws are common, and are conventionally treated using metallic or polymeric implants, which poorly bond to the surrounding bone. As a result, failure of such implants is common.

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Podcast on Biofabrication

Prof. Moroni was interviewed by Future Tech Podcast on Biofabrication and its promise for regenerative medicine and pharmaceutical applications as 3D in vitro models.

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Biofabrication for the eardrum
Published on: August 19, 2018
Category: Events

Current approaches used for eardrum repair or replacement show sub-optimal hearing outcomes. 4NanoEARDRM aims at filling an exposed gap in COM treatment by providing biomimetic, reliable and highly performant eardrum devices provided with targeted drug delivery and anti-inflammatory activity, finally enabling in situ tympanic membrane regeneration with optimal acoustics. The 4NanoEARDRM device is conceived to be “4 times” “nano”, as it will have nanofibres supportive for cell repopulation, immunomodulatory nanofibrils, drug-delivery nanoparticles, and nanoscale vibration. At the same time, it will be “for” “Nano”, namely, for enabling exploitable nanotechnologies and nanomedicine products in otologic surgery.

As part of a Euronanomed project, we will be working together with partners from Italy, Germany, and Turkey.