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Towards Kidney bioprinting

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SINERGIA: biofabrication for 3D in vitro models

We are excited to have been selected for funding in a Marie Curie project called SINERGIA, which aims at developing advanced models of human physiology and diseases, to be ultimately introduced in the preclinical stages of the drug discovery pipeline.

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Moroni Lab Broadcasted on Biofabrication

Biofabrication has witnessed several advances in this past months, spanning from new technologies, to promising steps forward in several tissue regeneration applications.

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Mimicking Tissue Organization at Multiple Scales with Biofabrication

Many tissues in our body display a variable degree of fiber curliness, which is crucial for their biomechanical behaviour. Methods to replicate such features in scaffolds for regenerative medicine are limited. Here, we show how by simply applying controlled buckling to electrospun fibers, we can fabricate scaffolds with different degrees of fiber waviness at multiple scales.

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Towards Kidney bioprinting

Certainly bioprinting of a full kidney remains a dream. It will be probably like that for many decades, unless a strong and well funded collaborative effort will be originated in the near future. However, current kidney bioprinting attempts are helping creating more know-how over kidney biology through the biofabrication of 3D in vitro models that can be used to study new treatments for kidney chronic conditions.

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World TERMIS 2021

After Seoul, Vienna, and Boston, Maastricht was selected to host the next world conference of the tissue engineering and regenerative medicine society. We expect to attract more than 2'000 delegates by 2021 in Maastricht, which is at the center of a European region fervidly active in tissue engineering, regenerative medicine, stem cells, biomaterials, in silico modeling, and biofabrication.

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Towards Kidney bioprinting
Published on: January 12, 2019
Category: Events

In this direction, we have started since 3 years to work on kidney bioprinting, with collaborations in Germany, Canada, and United Kingdom. Thanks to the leadership of Carlos Mota, asistant professor in the group, and his team we now have a better grip over the differentiation of stem cells into kidney progenitors to regenerate several of the specialized cells present in a kidney. We have devised new bioinks to maintain these cells alive during bioprinting and are currently studying differentiation processes in the bioprinted 3D in vitro models.

Carlos has also talked about the curent state of the art and challenges in a couplef interviews. To know more:

https://www.nemokennislink.nl/publicaties/nierweefsel-uit-de-3d-printer/ (in Dutch);

https://www.maastrichtuniversity.nl/news/um-institute-merln-will-develop-kidney-tissue-using-3d-bioprinting (in English);

 https://www.trouw.nl/home/stel-je-voor-een-verloren-been-groeit-vanzelf-aan~a4d095f4/ (in Dutch)