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Towards Kidney bioprinting

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New Hybrid Biofabrication technology

Many tissues in our body display gradients. These are not only biological gradients, but also structural, physical, and chemical ones, resulting in smoother variations of mechanical properties and cell functional activity.

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Kidney 3D in vitro models through bioprinting

At the Complex Tissue Regeneration department, we work hard to bridge the gap towards the dream of organs bioprinting. Step by step, we are now progressing towards understanding more and more in depth the requirements to bioprint different kidney cells, either derived from pluripotent stem cells or of adult species.

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Bioprinting through Levitation

Magnetic levitation offers the possibility to place cells in a precise position in space through controlling the magnetic forces applied to magnetized cells. This new biofabrication technique, at the interface between bioprinting and bioassembly, provides new ways to create large-scale biological constructs that can be used for regenerative medicine purposes.

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SINERGIA: biofabrication for 3D in vitro models

We are excited to have been selected for funding in a Marie Curie project called SINERGIA, which aims at developing advanced models of human physiology and diseases, to be ultimately introduced in the preclinical stages of the drug discovery pipeline.

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Moroni Lab Broadcasted on Biofabrication

Biofabrication has witnessed several advances in this past months, spanning from new technologies, to promising steps forward in several tissue regeneration applications.

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Towards Kidney bioprinting
Published on: January 12, 2019
Category: Events

In this direction, we have started since 3 years to work on kidney bioprinting, with collaborations in Germany, Canada, and United Kingdom. Thanks to the leadership of Carlos Mota, asistant professor in the group, and his team we now have a better grip over the differentiation of stem cells into kidney progenitors to regenerate several of the specialized cells present in a kidney. We have devised new bioinks to maintain these cells alive during bioprinting and are currently studying differentiation processes in the bioprinted 3D in vitro models.

Carlos has also talked about the curent state of the art and challenges in a couplef interviews. To know more:

https://www.nemokennislink.nl/publicaties/nierweefsel-uit-de-3d-printer/ (in Dutch);

https://www.maastrichtuniversity.nl/news/um-institute-merln-will-develop-kidney-tissue-using-3d-bioprinting (in English);

 https://www.trouw.nl/home/stel-je-voor-een-verloren-been-groeit-vanzelf-aan~a4d095f4/ (in Dutch)