SINERGIA: biofabrication for 3D in vitro models
We are excited to have been selected for funding in a Marie Curie project called SINERGIA, which aims at developing advanced models of human physiology and diseases, to be ultimately introduced in the preclinical stages of the drug discovery pipeline.
Moroni Lab Broadcasted on Biofabrication
Biofabrication has witnessed several advances in this past months, spanning from new technologies, to promising steps forward in several tissue regeneration applications.
Mimicking Tissue Organization at Multiple Scales with Biofabrication
Many tissues in our body display a variable degree of fiber curliness, which is crucial for their biomechanical behaviour. Methods to replicate such features in scaffolds for regenerative medicine are limited. Here, we show how by simply applying controlled buckling to electrospun fibers, we can fabricate scaffolds with different degrees of fiber waviness at multiple scales.
Towards Kidney bioprinting
Certainly bioprinting of a full kidney remains a dream. It will be probably like that for many decades, unless a strong and well funded collaborative effort will be originated in the near future. However, current kidney bioprinting attempts are helping creating more know-how over kidney biology through the biofabrication of 3D in vitro models that can be used to study new treatments for kidney chronic conditions.
World TERMIS 2021
After Seoul, Vienna, and Boston, Maastricht was selected to host the next world conference of the tissue engineering and regenerative medicine society. We expect to attract more than 2'000 delegates by 2021 in Maastricht, which is at the center of a European region fervidly active in tissue engineering, regenerative medicine, stem cells, biomaterials, in silico modeling, and biofabrication.
Biofabrication for the eardrum
Tympanic membrane (or eardrum) is provided by nature with unique anatomic features that ultimately allow a superb physiologic performance in varying frequency ranges. Several pathologies damage this tissue, including chronic otitis media (COM), which ultimately bring to deafness.
Biofabrication with dynamic materials
3D printing makes it possible to create complex personalized products such as prostheses and implants directly from a 3D scan. To make this type of application possible, it is important that available materials have the correct mechanical and biochemical properties. In the TA program DYNAM, which is funded from the Innovation Fund for Chemistry, researchers and companies will tackle this challenge
New Project on 3D printing
Damaged and diseased bones in the region of head, face and jaws are common, and are conventionally treated using metallic or polymeric implants, which poorly bond to the surrounding bone. As a result, failure of such implants is common.
Podcast on Biofabrication
Prof. Moroni was interviewed by Future Tech Podcast on Biofabrication and its promise for regenerative medicine and pharmaceutical applications as 3D in vitro models.
Biofabrication for Nerves
In our recent review published in the January issue of Advanced Healthcare Materials, we have reported on recent advances in the biofabrication field to regenerate peripheral nerves.
FET FLAGSHIP Proposal on Personalized Health Care Initiative
The Personalised Health Care Initiative is a large-scale scientific and technological proposal that will address the grand challenge of developing regenerative, precision and personalised medicine to improve the quality of life of billions of patients worldwide.
Writing with Electrospinning
Direct Writing Electrospinning allows the deposition of bundles of fibers in a predetermined pattern, thus mimicking more closely the structural architecture of our native extracellular matrix.