Application of biofabrication technologies

Apply biofabrication technologies to study regenerative and degenerative phenomena

With biofabrication platforms, it will be possible in the near future (short-term) to control the differentiation of (stem) cells, and create (medium-term) vascularized and innervated complex organs to better integrate with the surrounding tissues in the implantation site. These constructs could also serve as in vitro 3D models (long-term) to study mechanisms and possible therapies behind pathological conditions (e.g. bone models to study cancer metastasis) or organ regeneration (e.g. pancreas, kidney, glands). In this research line, other enabling technologies will be fundamental for the rationale development of functional constructs (e.g. modeling), and for characterization of the engineered tissues (e.g. imaging, biochemical, mechanical, and molecular analysis). This will be fed back into the design of biofabricated constructs to achieve on one side a better 3D construct, on the other side possible new therapies for targeted diseases. 

Researchers involved in this project

Khadija Mulder, Jip Zonderland, David Gomes, Afonso Malheiro, Rabeil Sakina, Sara Neves, Tianyu Yao, Abishek Harichandan, Paul Wieringa, Carlos Mota, Febriyani Damanik

Related publications

  1. Mota C, Danti S, D'Alessandro D, Trombi L, Ricci C, Puppi D, Dinucci D, Milazzo M, Stefanini C, Chiellini F, Moroni L, Berrettini S. Multiscale fabrication of biomimetic scaffolds for tympanic membrane tissue engineering. Biofabrication. 2015 May 7;7(2):025005

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  2. Marchioli G, van Gurp L, van Krieken PP, Stamatialis D, Engelse M, van Blitterswijk CA, Karperien MB, de Koning E, Alblas J, Moroni L, van Apeldoorn AA. Fabrication of three-dimensional bioplotted hydrogel scaffolds for islets of Langerhans transplantation. Biofabrication 2015, May 28;7(2):025009.

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  3. Hendrikson WJ, Zeng X, Rouwkema J, van Blitterswijk CA, van der Heide E, Moroni L. Biological and Tribological Assessment of Poly(Ethylene Oxide Terephthalate)/Poly(Butylene Terephthalate), Polycaprolactone, and Poly (L\DL) Lactic Acid Plotted Scaffolds for Skeletal Tissue Regeneration. Adv Healthc Mater. 2016 Jan;5(2):232-43.

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  4. Hendriks JAA, Moroni L, Riesle J, de Wijn JR, van Blitterswijk CA. The effect of scaffold-cell entrapment capacity and physico-chemical properties on cartilage regeneration. Biomaterials 2013; 34(17): 4259-65.

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  5. Moroni L, Elisseeff JH. Biomaterials engineered for integration. Materials Today 2008; 11(5): 44-51.

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